Incorporating Time Delays in Process Hitting Framework for Dynamical Modeling of Large Biological Regulatory Networks.

ABSTRACT: Modeling and simulation of molecular systems helps in understanding the behavioral mechanism of biological regulation. Time delays in production and degradation of expressions are important parameters in biological regulation. Constraints on time delays provide insight into the dynamical behavior of a Biological Regulatory Network (BRN). A recently introduced Process Hitting (PH) Framework has been found efficient in static analysis of large BRNs, however, it lacks the inference of time delays and thus determination of their constraints associated with the evolution of the expression levels of biological entities of BRN is not possible. In this paper we propose a Hybrid Process Hitting scheme for introducing time delays in Process Hitting Framework for dynamical modeling and analysis of La

SUBMITTER: Sheikh IA 

PROVIDER: S-EPMC6385622 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature