Long-term Absolute Risk for Cardiovascular Disease Stratified by Fasting Glucose Level.

ABSTRACT:

Objective

To estimate the long-term absolute risk for cardiovascular disease (CVD) according to fasting glucose (FG) levels below the threshold of diabetes.

Research design and methods

We pooled data from seven observational cohorts of U.S. black and white men and women followed from 1960 to 2015. We categorized FG as follows: <5.0, 5.0-5.5, 5.6-6.2, 6.3-6.9 mmol/L, and diabetes (FG ≥7.0 mmol/L or use of diabetes medications). CVD was defined as fatal/nonfatal coronary heart disease and fatal/nonfatal stroke. We estimated the risk of CVD by FG category at index age 55 years using a modified Kaplan-Meier survival analysis, adjusted for the competing risk of non-CVD death. We also assessed risk for incident CVD according to change in FG before 50 years of age, specifically amo

SUBMITTER: Bancks MP 

PROVIDER: S-EPMC6385698 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature