Quantitative impact of changes in marrow cellularity, skeletal size, and bone mineral density on active marrow dosimetry based upon a reference model.

ABSTRACT:

Purpose

The hematopoietically active tissues of skeletal bone marrow are a prime target for computational dosimetry given potential risks of leukemia and, at higher dose levels, acute marrow toxicity. The complex three-dimensional geometry of trabecular spongiosa, however, complicates schema for dose assessment in such a way that only a few reference skeletal models have been developed to date, and which are based upon microimaging of a limited number of cadaveric bone spongiosa cores. The question then arises as to what degree of accuracy is achievable from reference skeletal dose models when applied to individual patients or specific exposed populations?

Methods

Patient variability in marrow dosimetry were quantified for three skeletal sites - the ribs, lumbar vertebrae, a

SUBMITTER: Geyer AM 

PROVIDER: S-EPMC6385860 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature