Self-injurious behaviours in rhesus macaques: Potential glial mechanisms.

ABSTRACT:

Background

Self-injurious behaviour (SIB) can be classified as intentional, direct injuring of body tissue usually without suicidal intent. In its non-suicidal form it is commonly seen as a clinical sign of borderline personality disorder, autism, PTSD, depression, and anxiety affecting a wide range of ages and conditions. In rhesus macaques SIB is most commonly manifested through hair plucking, self-biting, self-hitting, and head banging. SIB in the form of self-biting is observed in approximately 5-15% of individually housed monkeys. Recently, glial cells are becoming recognised as key players in regulating behaviours.

Method

The goal of this study was to determine the role of glial activation, including astrocytes, in macaques that had displayed SIB. To this end, we perfo

SUBMITTER: Ramsey J 

PROVIDER: S-EPMC6385863 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature