fac-^99mTc/Re-tricarbonyl complexes with tridentate aminocarboxyphosphonate ligands: suitability of the phosphonate group in chelate ligand design of new imaging agents.

ABSTRACT: Ligands that coordinate via dianionic phosphonate groups have not been widely utilized in radiopharmaceuticals. N-(phosphonomethyl)iminodiacetic acid (1, PMIDA) and N-(phosphonomethyl)glycine (2, PMG) were investigated as new chelators for the ^99mTc/Re-tricarbonyl "core" (fac-M(CO)₃, M = ^99mTc, Re) present in a major class of radiopharmaceuticals. fac-M(CO)₃(PMIDA) and fac-M(CO)₃(PMG) complexes were studied by HPLC and ¹H/¹³C/³¹P NMR methods for M = Re (Re-1 and Re-2) and by HPLC for M = ^99mTc ( ^99m Tc-1 and ^99m Tc-2). Re-1 and ^99m Tc-1 complexes exhibit a similar pH-dep

SUBMITTER: Lipowska M 

PROVIDER: S-EPMC6385875 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature