Building blocks for recognition-encoded oligoesters that form H-bonded duplexes.

ABSTRACT: Competition from intramolecular folding is a major challenge in the design of synthetic oligomers that form intermolecular duplexes in a sequence-selective manner. One strategy is to use very rigid backbones that prevent folding, but this design can prejudice duplex formation if the geometry is not exactly right. The alternative approach found in nucleic acids is to use bases (or recognition units) that have different dimensions. A long-short base-pairing scheme makes folding geometrically difficult and is compatible with the flexible backbones that are required to guarantee duplex formation. A monomer building block equipped with a long hydrogen bond donor (phenol, D) recognition unit and a monomer building block equipped with a short hydrogen bond acceptor (phosphine oxide, A</

SUBMITTER: Szczypinski FT 

PROVIDER: S-EPMC6385898 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature