Drugs Contributing to Anticholinergic Burden and Risk of Fall or Fall-Related Injury among Older Adults with Mild Cognitive Impairment, Dementia and Multiple Chronic Conditions: A Retrospective Cohort Study.

ABSTRACT:

Background

It is not known whether drugs with different anticholinergic ratings contribute proportionately to overall anticholinergic score.

Objectives

Our objective was to assess the risk of falls or fall-related injuries as a function of the overall anticholinergic score resulting from drugs with different anticholinergic ratings among people with impaired cognition.

Methods

This was a retrospective cohort study of adults aged  ≥ 65 years with mild cognitive impairment (MCI) or dementia and two or more additional chronic conditions (N = 10,698) in an integrated delivery system. Electronic health record data, including pharmacy fills and diagnosis claims, were used to assess anticholinergic medication use, quantified using the anticholinergic cognitive burden (ACB) s

SUBMITTER: Green AR 

PROVIDER: S-EPMC6386184 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature