Effects of chronic cannabinoid exposure during adolescence on reward preference and mPFC activation in adulthood.

ABSTRACT: Cannabis is one of the most commonly used drugs among adolescents, with initial use beginning between the ages of 12 to 17. Although often perceived as a 'soft drug', both short- and long-term use have been associated with numerous adverse outcomes, including cognitive impairment, increased risk of substance abuse, and heightened risk of psychosis or schizophrenia in individuals with a predisposition. Further, the severity of these impairments is closely linked to initiation of use, i.e. earlier use increases risk. It has been suggested that adolescent vulnerability to the adverse consequences of cannabis use is due to ongoing brain development occurring during this time. Indeed, the adolescent brain continues to be remodeled well into adolescence and early adulthood, particularly in the p

SUBMITTER: Jacobs-Brichford E 

PROVIDER: S-EPMC6386194 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature