Cost-effectiveness of secukinumab compared to other biologics in the treatment of ankylosing spondylitis in Finland.

ABSTRACT:

Aim

This study assesses the cost-effectiveness of secukinumab vs currently licensed biologics for the treatment of ankylosing spondylitis (AS) from the Finnish health care system perspective.

Methods

A semi-Markov model compared secukinumab with adalimumab, adalimumab biosimilar, certolizumab pegol, etanercept, etanercept biosimilar, golimumab, and infliximab in a biologic-naïve population over a lifetime horizon. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) was used to assess the treatment response. Efficacy inputs were obtained from the network meta-analysis, and other model inputs were obtained from the published literature and Finnish sources. Main study outcomes included quality-adjusted life years (QALYs) gained and incremental cost-effectiveness rat

SUBMITTER: Purmonen T 

PROVIDER: S-EPMC6386207 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature