Bald thigh syndrome in sighthounds-Revisiting the cause of a well-known disease.

ABSTRACT: Bald thigh syndrome is a common hair loss disorder in sighthounds. Numerous possible causes, including environmental conditions, trauma, stress, endocrinopathies and genetic components have been proposed, but only endocrinopathies have been ruled out scientifically. The overall goal of our study was to identify the cause of bald thigh syndrome and the pathological changes associated with it. We approached this aim by comparing skin biopsies and hair shafts of affected and control dogs microscopically as well as by applying high-throughput technologies such as genomics, transcriptomics and proteomics. While the histology is rather unspecific in most cases, trichogram analysis and scanning electron microscopy revealed severe structural abnormalities in hair shafts of affected dogs. This find

SUBMITTER: Brunner MAT 

PROVIDER: S-EPMC6386255 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature