Aerosol vaccination with Bacille Calmette-Guerin induces a trained innate immune phenotype in calves.

ABSTRACT: Mycobacterium bovis Bacillus Calmette-Guérin (BCG) is a live attenuated vaccine for use against tuberculosis (TB); however, it is known to reduce childhood mortality from infections other than TB. The unspecific protection induced by BCG vaccination has been associated with the induction of memory-like traits of the innate immune system identified as 'trained' immunity. In humans and mouse models, in vitro and in vivo BCG training leads to enhanced production of monocyte-derived proinflammatory cytokines in response to secondary unrelated bacterial and fungal pathogens. While BCG has been studied extensively for its ability to induce innate training in humans and mouse models, BCG's nonspecific protective effects have not been defined in agricultural species. Here, we show that in vitro BC

SUBMITTER: Guerra-Maupome M 

PROVIDER: S-EPMC6386280 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature