Omentin protects H9c2 cells against docetaxel cardiotoxicity.

ABSTRACT:

Background

Association between obesity and cardiovascular diseases is well known, however increased susceptibility of obese patients to develop several cancer types is not so commonly known. Current data suggest that poorer overall survival in cancer patients might be associated to non-cancer-related causes such as higher risk of cardiotoxicity in obese patients treated with chemotherapeutic agents. Omentin, a novel adipokine decreased in obesity, is actually in the spotlight due to its favourable effects on inflammation, glucose homeostasis and cardiovascular diseases. Also, recent data showed that in vitro anthracycline-induced cardiomyocyte apoptosis is counteracted by omentin suggesting its cardioprotective role.

Objective

Our aim was to evaluate omentin effects against

SUBMITTER: Lage R 

PROVIDER: S-EPMC6386316 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature