Hybrid multivariate pattern analysis combined with extreme learning machine for Alzheimer's dementia diagnosis using multi-measure rs-fMRI spatial patterns.

ABSTRACT:

Background

Early diagnosis of Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) is essential for timely treatment. Machine learning and multivariate pattern analysis (MVPA) for the diagnosis of brain disorders are explicitly attracting attention in the neuroimaging community. In this paper, we propose a voxel-wise discriminative framework applied to multi-measure resting-state fMRI (rs-fMRI) that integrates hybrid MVPA and extreme learning machine (ELM) for the automated discrimination of AD and MCI from the cognitive normal (CN) state.

Materials and methods

We used two rs-fMRI cohorts: the public Alzheimer's disease Neuroimaging Initiative database (ADNI2) and an in-house Alzheimer's disease cohort from South Korea, both including individuals with AD, MCI, and no

SUBMITTER: Nguyen DT 

PROVIDER: S-EPMC6386400 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature