A natural variant and engineered mutation in a GPCR promote DEET resistance in C. elegans.

ABSTRACT: DEET (N,N-diethyl-meta-toluamide) is a synthetic chemical identified by the US Department of Agriculture in 1946 in a screen for repellents to protect soldiers from mosquito-borne diseases^1,2. Since its discovery, DEET has become the world's most widely used arthropod repellent and is effective against invertebrates separated by millions of years of evolution-including biting flies³, honeybees⁴, ticks⁵, and land leeches³. In insects, DEET acts on the olfactory system^5-12 and requires the olfactory receptor co-receptor Orco^7,9-12, but exactly how it works remains controversial¹³. Here we show that the nematode Caenorhabditis elegans is sensitive to DEET and use this genetically tractable animal to study

SUBMITTER: Dennis EJ 

PROVIDER: S-EPMC6386462 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature