The impact of pathological high-frequency oscillations on hippocampal network activity in rats with chronic epilepsy.

ABSTRACT: In epilepsy, brain networks generate pathological high-frequency oscillations (pHFOs) during interictal periods. To understand how pHFOs differ from normal oscillations in overlapping frequency bands and potentially perturb hippocampal processing, we performed high-density single unit and local field potential recordings from hippocampi of behaving rats with and without chronic epilepsy. In epileptic animals, we observed two types of co-occurring fast oscillations, which by comparison to control animals we could classify as 'ripple-like' or 'pHFO'. We compared their spectral characteristics, brain state dependence, and cellular participants. Strikingly, pHFO occurred irrespective of brain state, were associated with interictal spikes, engaged distinct subnetworks of principal neurons compa

SUBMITTER: Ewell LA 

PROVIDER: S-EPMC6386518 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature