Determining success rates of the current pharmacokinetically guided dosing approach of topotecan in pediatric oncology patients.

ABSTRACT: BACKGROUND:Topotecan is a chemotherapeutic agent that is active against many pediatric tumors. Although its effect is related to systemic exposure, the interpatient variability in systemic clearance makes it challenging to achieve desired topotecan targets. This study aims to evaluate the success of the pharmacokinetically (PK) guided dosing process, which was used to achieve a target topotecan area under the concentration-time curve (AUC). METHODS:Patients received an empiric topotecan dosage on the first day; the topotecan lactone AUC was determined, and based upon these values the topotecan dosage was adjusted. The success rates of both the empiric and PK-guided strategies were calculated. Patient-specific covariates were collected to explain variability observed in the empiric and PK-g

SUBMITTER: Mitchell AB 

PROVIDER: S-EPMC6386591 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature