Differences in the genetic backgrounds of patients with alcoholic liver disease and non-alcoholic fatty liver disease.

ABSTRACT:

Background and aim

Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) have common hepatic histological features, but few studies have compared the genomic backgrounds of these two diseases. Here, we compared the genetic differences between ALD and NAFLD.

Methods

This study enrolled 318 Japanese patients with ALD (n = 118; male, 86%; median age, 62 years; liver cirrhosis, 58%; hepatocellular carcinoma [HCC], 31%) and NAFLD (n = 200; male, 55%; age, 61 years; cirrhosis, 19%; HCC, 12%). The genotype frequencies of 10 single nucleotide polymorphisms (SNPs) were analyzed.

Results

The ADH1B genotype GG and ALDH2 genotype GG were observed more frequently, and the percentage of patients with the MTP genotype GG was l

SUBMITTER: Yamamoto K 

PROVIDER: S-EPMC6386744 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature