Dysregulation of Adenosinergic Signaling in Systemic and Organ-Specific Autoimmunity.

ABSTRACT: Exact causes for autoimmune diseases remain unclear and no cures are available. Breakdown of immunotolerance could set the stage for unfettered immune responses that target self-antigens. Impaired regulatory immune mechanisms could have permissive roles in autoreactivity. Abnormal regulatory immune cell function, therefore, might be a major determinant of the pathogenesis of autoimmune disease. All current treatments are associated with some level of clinical toxicity. Treatment to specifically target dysregulated immunity in these diseases would be a great advance. Extracellular adenosine is a signaling mediator that suppresses inflammation through activation of P1 receptors, most active under pathological conditions. Mounting evidence has linked alterations in the generation of adenosine

SUBMITTER: Vuerich M 

PROVIDER: S-EPMC6386992 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature