The Role of the CopA Copper Efflux System in Acinetobacter baumannii Virulence.

ABSTRACT: Acinetobacter baumannii has emerged as one of the leading causative agents of nosocomial infections. Due to its high level of intrinsic and adapted antibiotic resistance, treatment failure rates are high, which allows this opportunistic pathogen to thrive during infection in immune-compromised patients. A. baumannii can cause infections within a broad range of host niches, with pneumonia and bacteraemia being associated with the greatest levels of morbidity and mortality. Although its resistance to antibiotics is widely studied, our understanding of the mechanisms required for dealing with environmental stresses related to virulence and hospital persistence, such as copper toxicity, is limited. Here, we performed an in silico analysis of the A. baumannii copper resisto

SUBMITTER: Alquethamy SF 

PROVIDER: S-EPMC6387184 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature