HIV-Associated Cryptococcal Meningitis Occurring at Relatively Higher CD4 Counts.

ABSTRACT:

Background

Cryptococcal meningitis can occur in persons with less-apparent immunosuppression. We evaluated clinical characteristics and outcomes of persons with HIV-related Cryptococcus presenting with higher CD4 counts.

Methods

We enrolled 736 participants from 2 prospective cohorts in Uganda and South Africa from November 2010 to May 2017. We compared participants with CD4 <50, 50-99, or ≥100 cells/μL by clinical characteristics, cerebrospinal fluid (CSF) parameters, and 18-week survival.

Results

Among first episode of cryptococcosis, 9% presented with CD4 ≥100 cells/μL. Participants with CD4 ≥100 cells/μL presented more often with altered mental status (52% vs 39%; P = .03) despite a 10-fold lower initial median CSF fungal burden of 7850 (interquartile range [IQR]

SUBMITTER: Tugume L 

PROVIDER: S-EPMC6387427 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature