Acute neuropathological consequences of short-term mechanical ventilation in wild-type and Alzheimer's disease mice.

ABSTRACT:

Background

Mechanical ventilation is strongly associated with cognitive decline after critical illness. This finding is particularly evident among older individuals who have pre-existing cognitive impairment, most commonly characterized by varying degrees of cerebral amyloid-β accumulation, neuroinflammation, and blood-brain barrier dysfunction. We sought to test the hypothesis that short-term mechanical ventilation contributes to the neuropathology of cognitive impairment by (i) increasing cerebral amyloid-β accumulation in mice with pre-existing Alzheimer's disease pathology, (ii) increasing neurologic and systemic inflammation in wild-type mice and mice with pre-existing Alzheimer's disease pathology, and (iii) increasing hippocampal blood-brain barrier permeability in wild-type

SUBMITTER: Lahiri S 

PROVIDER: S-EPMC6387486 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature