LincK contributes to breast tumorigenesis by promoting proliferation and epithelial-to-mesenchymal transition.

ABSTRACT:

Background

Increasing evidence has demonstrated that mesenchymal stem cells (MSCs) play a role in the construction of tumor microenvironments. Co-culture between tumor cells and MSCs provides an easy and useful platform for mimicking tumor microenvironments and identifying the important members involved in tumor progress. The long non-coding RNAs (lncRNAs) have been shown to regulate different tumorigenic processes. In this study, we aimed to examine functional lncRNA deregulations associated with breast cancer malignancy instigated by MSC-MCF-7 co-culture.

Methods

The microarrays were used to profile the expression changes of lncRNAs in MCF-7 cells during epithelial-mesenchymal transition (EMT) induced by co-culture with MSCs. We found that an intergenic lncRNA KB-1732A1.1

SUBMITTER: Li J 

PROVIDER: S-EPMC6387548 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature