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Catalytic One-Step Deoxytrifluoromethylation of Alcohols.

ABSTRACT: A new bench-stable trifluoromethylation reagent, phenyl bromodifluoroacetate, converts readily available alcohols to trifluoromethanes in a Cu-catalyzed deoxytrifluoromethylation reaction. This reaction streamlines access to target biologically active molecules, and should be useful for a variety of medicinal, agricultural, and materials chemists.

SUBMITTER: de Azambuja F 

PROVIDER: S-EPMC6387626 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Catalytic One-Step Deoxytrifluoromethylation of Alcohols.

de Azambuja Francisco F   Lovrien Sydney M SM   Ross Patrick P   Ambler Brett R BR   Altman Ryan A RA  

The Journal of organic chemistry 20190125 4

A new bench-stable trifluoromethylation reagent, phenyl bromodifluoroacetate, converts readily available alcohols to trifluoromethanes in a Cu-catalyzed deoxytrifluoromethylation reaction. This reaction streamlines access to target biologically active molecules, and should be useful for a variety of medicinal, agricultural, and materials chemists. ...[more]

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