Gaps and opportunities in refractory status epilepticus research in children: a multi-center approach by the Pediatric Status Epilepticus Research Group (pSERG).

ABSTRACT:

Purpose

Status epilepticus (SE) is a life-threatening condition that can be refractory to initial treatment. Randomized controlled studies to guide treatment choices, especially beyond first-line drugs, are not available. This report summarizes the evidence that guides the management of refractory convulsive SE (RCSE) in children, defines gaps in our clinical knowledge and describes the development and works of the 'pediatric Status Epilepticus Research Group' (pSERG).

Methods

A literature review was performed to evaluate current gaps in the pediatric SE and RCSE literature. In person and online meetings helped to develop and expand the pSERG network.

Results

The care of pediatric RCSE is largely based on extrapolations of limited evidence derived from adult literatur

SUBMITTER: Sanchez Fernandez I 

PROVIDER: S-EPMC6387832 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature