EpiProfile 2.0: A Computational Platform for Processing Epi-Proteomics Mass Spectrometry Data.

ABSTRACT: Epigenetics has become a fundamental scientific discipline with various implications for biology and medicine. Epigenetic marks, mostly DNA methylation and histone post-translational modifications (PTMs), play important roles in chromatin structure and function. Accurate quantification of these marks is an ongoing challenge due to the variety of modifications and their wide dynamic range of abundance. Here we present EpiProfile 2.0, an extended version of our 2015 software (v1.0), for accurate quantification of histone peptides based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. EpiProfile 2.0 is now optimized for data-independent acquisition through the use of precursor and fragment extracted ion chromatography to accurately determine the chromatographic profile a

SUBMITTER: Yuan ZF 

PROVIDER: S-EPMC6387837 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature