Receptor-Receptor Interactions as a Widespread Phenomenon: Novel Targets for Drug Development?

ABSTRACT: The discovery of receptor-receptor interactions (RRI) has expanded our understanding of the role that G protein-coupled receptors (GPCRs) play in intercellular communication. The finding that GPCRs can operate as receptor complexes, and not only as monomers, suggests that several different incoming signals could already be integrated at the plasma membrane level via direct allosteric interactions between the protomers that form the complex. Most research in this field has focused on neuronal populations and has led to the identification of a large number of RRI. However, RRI have been seen to occur not only in neurons but also in astrocytes and, outside the central nervous system, in cells of the cardiovascular and endocrine systems and in cancer cells. Furthermore, RRI involving the forma

SUBMITTER: Guidolin D 

PROVIDER: S-EPMC6387912 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature