The Association of Childhood Maltreatment With Lipid Peroxidation and DNA Damage in Postpartum Women.

ABSTRACT: Childhood maltreatment (CM) is associated with an increased risk for the development of psychiatric and somatic disorders in later life. A potential link could be oxidative stress, which is defined as the imbalance between the amount of reactive oxygen species (ROS) and the neutralizing capacity of anti-oxidative defense systems. However, the findings linking CM with oxidative stress have been inconsistent so far. In this study, we aimed to further explore this association by investigating biological markers of DNA and lipid damage due to oxidation in a comprehensive approach over two study cohorts of postpartum women (study cohort I and study cohort II). The severity of CM experiences (maltreatment load) was assessed in both studies using the Childhood Trauma Questionnaire. In stud

SUBMITTER: Boeck C 

PROVIDER: S-EPMC6387959 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature