Mapping novel genetic loci associated with female liver weight variations using Collaborative Cross mice.

ABSTRACT:

Background

Liver weight is a complex trait, controlled by polygenic factors and differs within populations. Dissecting the genetic architecture underlying these variations will facilitate the search for key role candidate genes involved directly in the hepatomegaly process and indirectly involved in related diseases etiology.

Methods

Liver weight of 506 mice generated from 39 different Collaborative Cross (CC) lines with both sexes at age 20 weeks old was determined using an electronic balance. Genomic DNA of the CC lines was genotyped with high-density single nucleotide polymorphic markers.

Results

Statistical analysis revealed a significant (P < 0.05) variation of liver weight between the CC lines, with broad sense heritability (H ²) of 0.32

SUBMITTER: Abu-Toamih Atamni HJ 

PROVIDER: S-EPMC6388055 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature