Advanced Hepatitis C Virus Replication PDE Models within a Realistic Intracellular Geometric Environment.

ABSTRACT: The hepatitis C virus (HCV) RNA replication cycle is a dynamic intracellular process occurring in three-dimensional space (3D), which is difficult both to capture experimentally and to visualize conceptually. HCV-generated replication factories are housed within virus-induced intracellular structures termed membranous webs (MW), which are derived from the Endoplasmatic Reticulum (ER). Recently, we published 3D spatiotemporal resolved diffusion⁻reaction models of the HCV RNA replication cycle by means of surface partial differential equation (sPDE) descriptions. We distinguished between the basic components of the HCV RNA replication cycle, namely HCV RNA, non-structural viral proteins (NSPs), and a host factor. In particular, we evaluated the sPDE models upon realistic reconstructed intrac

SUBMITTER: Knodel MM 

PROVIDER: S-EPMC6388173 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature