Enhancement by Hydrogen Peroxide of Calcium Signals in Endothelial Cells Induced by 5-HT1B and 5-HT2B Receptor Agonists.

ABSTRACT: Hydrogen peroxide, formed in the endothelium, acts as a factor contributing to the relaxation of blood vessels. The reason for this vasodilatory effect could be modulation by H₂O₂ of calcium metabolism, since mobilization of calcium ions in endothelial cells is a trigger of endothelium-dependent relaxation. The aim of this work was to investigate the influence of H₂O₂ on the effects of Ca²⁺-mobilizing agonists in human umbilical vein endothelial cells (HUVEC). We have found that H₂O₂ in concentration range 10-100 μM increases the rise of [Ca²⁺]_i induced by 5-hydroxytryptamine (5-HT) and carbachol and does not affect the calcium signals of ATP, agonist of type 1 protease-activated recep

SUBMITTER: Avdonin PV 

PROVIDER: S-EPMC6388333 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature