Brazilian malaria molecular targets (BraMMT): selected receptors for virtual high-throughput screening experiments.

ABSTRACT:

Background

Owing to increased spending on pharmaceuticals since 2010, discussions about rising costs for the development of new medical technologies have been focused on the pharmaceutical industry. Computational techniques have been developed to reduce costs associated with new drug development. Among these techniques, virtual high-throughput screening (vHTS) can contribute to the drug discovery process by providing tools to search for new drugs with the ability to bind a specific molecular target.

Objectives

In this context, Brazilian malaria molecular targets (BraMMT) was generated to execute vHTS experiments on selected molecular targets of Plasmodium falciparum.

Methods

In this study, 35 molecular targets of P. falciparum were built and evaluated against known an

SUBMITTER: Nunes RR 

PROVIDER: S-EPMC6388387 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature