Diet-related inflammation and risk of prostate cancer in the California Men's Health Study.

ABSTRACT:

Purpose

The purpose of the study was to examine the relationship between proinflammatory diet and prostate cancer risk.

Methods

Energy-adjusted Dietary Inflammatory Index (E-DII) scores were computed among 40,161 participants in the California Men's Health Study. Over 9.7 ± 3.8 years of follow-up, 2707 incident prostate cancer cases were diagnosed and categorized as low-, intermediate-, or high-risk, based on disease grade and stage. Accelerated failure-time models assessed time to diagnosis of prostate cancer. Cox proportional hazard models estimated hazard ratios (HR) and 95% confidence intervals (95% CI). Nonlinear effects of E-DII were modeled as third-order polynomials.

Results

Time to prostate cancer diagnosis did not differ by E-DII quartile. The HR for high-ri

SUBMITTER: McMahon DM 

PROVIDER: S-EPMC6388401 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature