Induction and decay of functional complement-fixing antibodies by the RTS,S malaria vaccine in children, and a negative impact of malaria exposure.

ABSTRACT:

Background

Leading malaria vaccine, RTS,S, is based on the circumsporozoite protein (CSP) of sporozoites. RTS,S confers partial protection against malaria in children, but efficacy wanes relatively quickly after primary immunization. Vaccine efficacy has some association with anti-CSP IgG; however, it is unclear how these antibodies function, and how functional antibodies are induced and maintained over time. Recent studies identified antibody-complement interactions as a potentially important immune mechanism against sporozoites. Here, we investigated whether RTS,S vaccine-induced antibodies could function by interacting with complement.

Methods

Serum samples were selected from children in a phase IIb trial of RTS,S/AS02_A conducted at two study sites of high and

SUBMITTER: Kurtovic L 

PROVIDER: S-EPMC6388494 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature