HCC Immune Surveillance and Antiviral Therapy of Hepatitis C Virus Infection.

ABSTRACT:

Objective

HCV clearance by current antiviral therapies improves clinical outcomes but falls short in eliminating the risk for hepatocellular carcinoma (HCC) emergence. As the HCC immune surveillance establishment is vital for the control of neoplastic development and growth, we investigated its correlation with on-/post-treatment HCC emergence, and further analyzed the influence of viral eradication on this setup in patients with HCV-related liver cirrhosis.

Design

PBMC isolated at baseline and longitudinally during therapy were analyzed for tumor-associated antigen (TAA)-specific CD8+ T cell responses against glypican-3 overlapping peptides in vitro using high-definition flow cytometry. Multianalyte profiling of fifty soluble inflammatory mediators (SIM) in the plasma was a

SUBMITTER: Owusu Sekyere S 

PROVIDER: S-EPMC6388568 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature