Significant prognostic values of aquaporin mRNA expression in breast cancer.

ABSTRACT:

Introduction

Aquaporins (AQPs), also called water channels, have been shown to have functions in the migration, invasion, and proliferation of human breast tumor cells. Most AQP mRNA expression levels were tested by cell lines, mouse models, and even human breast tissues. However, the mRNA expression of individual AQPs in different clinicopathologic characteristics and prognostic values according to different kinds of classifications of breast cancer patients remains unclear.

Materials and methods

In the current study, we used the Oncomine database, Breast cancer Gene-Expression Miner v4.1, Kaplan-Meier Plotter, and cBioPortal to investigate the expression distribution and prognostic values of AQPs in breast cancer patients.

Results

Our study revealed that the mRNA ex

SUBMITTER: Zhu L 

PROVIDER: S-EPMC6388951 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature