Correlations of lncRNAs with cervical lymph node metastasis and prognosis of papillary thyroid carcinoma.

ABSTRACT:

Background

Cervical lymph node metastasis is an important prognostic indicator for papillary thyroid carcinoma (PTC) and affects treatment strategies for PTC. lncRNAs essentially contribute to the biological functions of tumors. This study aimed to identify the lncRNAs associated with cervical lymph node metastasis and prognosis of PTC and their potential pathophysiological mechanisms.

Materials and methods

PTC-associated lncRNAs were selected from The Cancer Genome Atlas database, and correlations among lncRNAs, lymph node metastasis, tumor staging, and prognosis of PTC were analyzed in silico. These correlations were then validated through quantitative reverse transcription PCR (qRT-PCR) and immunohistochemistry (IHC).

Results

In silico analysis showed that FAM95

SUBMITTER: Li N 

PROVIDER: S-EPMC6388952 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature