Promising diagnostic and prognostic value of E2Fs in human hepatocellular carcinoma.

ABSTRACT:

Background

A growing body of evidence suggests that E2Fs, by regulating gene expression related to cell cycle progression and other cellular processes, play a pivotal role in human cancer. However, the distinct roles of each E2F in the development and treatment of hepatocellular carcinoma (HCC) remain unknown. In the present study, the mRNA expression and prognostic value of different E2Fs in HCC are analyzed.

Materials and methods

Transcriptional and survival data related to E2F expression in patients with HCC were obtained through ONCOMINE and UALCAN databases. Survival analysis plots were drawn with Kaplan-Meier Plotter. The sequence alteration data for E2Fs were obtained from The Cancer Genome Atlas and c-BioPortal. Gene functional enrichment analyses were performed in D

SUBMITTER: Huang YL 

PROVIDER: S-EPMC6388971 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature