Apoptotic and antimetastatic activities of betulin isolated from Quercus incana against non-small cell lung cancer cells.

ABSTRACT:

Background

Globally, the prevalence and mortality rates of lung cancer have been escalated with the increasing trend of tobacco smoking. The toxicity and irresponsive nature of the available drugs for lung cancer treatment demands an alternative approach.

Methods

In this study, four known compounds namely, cirsimaritin (4',5, -dihydroxy-6,7-di-methoxyflavone) (1), eupatorin (5,3'-dihydroxy-6,7,4'-trimethoxyflavone) (2), betulin (Lup-20 (29)-ene-3, 28-diol) (3), and β-amyrin acetate (12-Oleanen-3yl acetate) (4) have been isolated from the leaves extract of Quercus incana. Preliminary screening of these natural compounds (1-4) was performed against non-small cell lung carcinoma (NCI-H460) and normal mouse fibroblast (NIH-3T3) cell lines.

Results

The compounds wer

SUBMITTER: Zehra B 

PROVIDER: S-EPMC6388989 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature