The distinct clinicopathological and prognostic implications of PIK3CA mutations in breast cancer patients from Central China.

ABSTRACT:

Purpose

The mutation status and prognostic value of PIK3CA in breast cancer were widely investigated, which showed significant difference among the patients from vast areas around the world. In this study, the frequency, distribution, bias, and burden of PIK3CA mutations and their relationships with clinicopathologic variables and prognostic significances were investigated in the breast cancer patients from Central China.

Materials and methods

Somatic mutations in exon 9 and exon 20 of PIK3CA gene were analyzed using Sanger sequencing combining with targeted next generation sequencing in 494 breast cancer patients from Central China. The correlations between PIK3CA mutations and clinicopathological characteristics and the prognostic values of mult

SUBMITTER: Wu H 

PROVIDER: S-EPMC6388997 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature