Claudin gene expression profiles and clinical value in colorectal tumors classified according to their molecular subtype.

ABSTRACT:

Purpose

Colorectal cancer (CRC) is a heterogeneous disease that can be classified into distinct molecular subtypes. The aims of this study were 1) to compare claudin (CLDN) gene expression in CRC samples and normal colon mucosa, and then in the different CRC molecular subtypes, and 2) to assess their prognostic value.

Patients and methods

CLDN expression in CRC samples was analyzed using gene expression data for a cohort of 143 primary CRC samples, and compared in the same CRC samples classified into different molecular subtypes (C1 to C6 according to the Marisa's classification, and CMS1 to CMS4 of the consensus classification). Comparison of CLDN expression in normal and tumor colon samples was also made on a smaller number of samples. Then, the relati

SUBMITTER: Cherradi S 

PROVIDER: S-EPMC6389001 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature