Upregulation of STC2 in colorectal cancer and its clinicopathological significance.

ABSTRACT:

Background

Stanniocalcin 2 (STC2) is a glycoprotein hormone involved in many biological processes and a secretory protein that regulates malignant tumor progression. The aim of the present study was to further explore the clinicopathological significance and prognostic role of STC2 in colorectal cancer (CRC).

Methods

In this study, STC2 expression was first investigated in Gene Expression Omnibus and The Cancer Genome Atlas, and then validated with the data from our medical center. Univariate and multivariate analyses were performed to assess the association between prognostic factors and survival outcome.

Results

In Gene Expression Omnibus and The Cancer Genome Atlas databases, bioinformatics analysis confirmed that STC2 was significantly increased in CRC compared wi

SUBMITTER: Zhang C 

PROVIDER: S-EPMC6389002 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature