FGG promotes migration and invasion in hepatocellular carcinoma cells through activating epithelial to mesenchymal transition.

ABSTRACT:

Purpose

The aim of this work was to investigate the clinicopathological significance of fibrinogen gamma chain (FGG) and its biological roles during hepatocellular carcinoma (HCC) development and progression.

Methods

The expression of FGG was examined by Western blot and reverse transcription quantitative PCR in two different sample sets, including 24 or 35 pairs of HCC tumor tissues and their corresponding adjacent non-tumorous tissues. Afterward, association analysis between the expression of FGG and clinicopathological characteristics was systematically analyzed in 79 HCC patients. Subsequently, the mobility and invasiveness of SK-HEP-1 cells with FGG overexpression or knockdown were evaluated by transwell assay and wound healing assay. Additionally, the expressions of ep

SUBMITTER: Zhang X 

PROVIDER: S-EPMC6389006 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature