Isoform specific gene expression analysis of KRAS in the prognosis of lung adenocarcinoma patients.

ABSTRACT:

Background

Aberrant mutations in KRAS play a critical role in tumor initiation and progression, and are a negative prognosis factor in lung adenocarcinoma (LUAD).

Results

Using genomic analysis for K-Ras isoforms (K-Ras4A and K-Ras4B) and large-scale multi-omics data, we inspected the overall survival (OS) and disease-free survival (DFS) of LUAD patients based on the abundance of transcript variants by analyzing RNA expression and somatic mutation data from The Cancer Genome Atlas (n = 516). The expression of the minor transcript K-Ras4A and its proportion were positively correlated with the presence of KRAS mutations in LUAD. We found that both K-Ras4A abundance measures (expression and proportion) have a strong association with poor OS (p = 0.0149 and p = 3.18E-3, respecti

SUBMITTER: Yang IS 

PROVIDER: S-EPMC6389035 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature