The association of Val109Asp polymorphic marker of intelectin 1 gene with abdominal obesity in Kyrgyz population.

ABSTRACT:

Background

The aim of this study was to quantify the association of Val109Asp polymorphism of intelectin 1 (ITLN1) gene with the abdominal obesity (AO) in Kyrgyz population.

Methods

Patients admitted to annual screening at a local outpatient facility were enrolled or this study. We genotyped 297 nonrelated adults of Kyrgyz ethnicity, of whom 127 were AO patients, including 46 men and 81 women with the mean age 53.2 ± 7.1 years, and 170 non-obese controls, including 61 men and 109 women with the mean age 52.0 ± 9.0 years. AO was defined as having waist circumferences ≥ 102 cm in men and ≥ 88 cm in women. We used PCR-RFLP method to define Val109Asp polymorphism of ITLN1 gene.

Results

Asp109Asp, Asp109Val and Val109Val genotypes were found in 48%, 40%, and 12% of AO pati

SUBMITTER: Isakova J 

PROVIDER: S-EPMC6389047 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature