Molecular profiling of lung cancer specimens and liquid biopsies using MALDI-TOF mass spectrometry.

ABSTRACT:

Background

Identification of predictive molecular alterations in lung adenocarcinoma is essential for accurate therapeutic decisions. Although several molecular approaches are available, a number of issues, including tumor heterogeneity, frequent material scarcity, and the large number of loci to be investigated, must be taken into account in selecting the most appropriate technique. MALDI-TOF mass spectrometry (MS), which allows multiplexed genotyping, has been adopted in routine diagnostics as a sensitive, reliable, fast, and cost-effective method. Our aim was to test the reliability of this approach in detecting targetable mutations in non-small cell lung cancer (NSCLC). In addition, we also analyzed low-quality samples, such as cytologic specimens, that often, are the unique so

SUBMITTER: Bonaparte E 

PROVIDER: S-EPMC6389067 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature