Effects of platelet-rich plasma on the activity of human menstrual blood-derived stromal cells in vitro.

ABSTRACT:

Background

Human menstrual blood-derived stromal cells (MenSCs) are highly proliferative and show multiple differentiation capacity. The convenience and non-invasiveness make MenSC a novel cell source for regenerative medicine applications. Platelet-rich plasma (PRP) contains abundant growth factors which are beneficial to wound healing. However, the influence of PRP on MenSCs remains elusive. Here, we evaluated the role of PRP in MenSCs proliferation and assessed the effects of PRP on endometrial receptivity regulation in vitro.

Methods

MenSCs cultured with 10% activated PRP were compared with those cultured with 10% fetal bovine serum (FBS). Differences in cell proliferation, differentiation, and endometrial receptivity-related gene expression were evaluated.

Results

SUBMITTER: Zhang S 

PROVIDER: S-EPMC6389087 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature