Distinct core promoter codes drive transcription initiation at key developmental transitions in a marine chordate.

ABSTRACT:

Background

Development is largely driven by transitions between transcriptional programs. The initiation of transcription at appropriate sites in the genome is a key component of this and yet few rules governing selection are known. Here, we used cap analysis of gene expression (CAGE) to generate bp-resolution maps of transcription start sites (TSSs) across the genome of Oikopleura dioica, a member of the closest living relatives to vertebrates.

Results

Our TSS maps revealed promoter features in common with vertebrates, as well as striking differences, and uncovered key roles for core promoter elements in the regulation of development. During spermatogenesis there is a genome-wide shift in mode of transcription initiation characterized by a novel core promoter element. This

SUBMITTER: Danks GB 

PROVIDER: S-EPMC6389100 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature