Cross-communication between G_i and G_s in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain.

ABSTRACT:

Background

G-protein-coupled receptor (GPCR) heteromeric complexes have distinct properties from homomeric GPCRs, giving rise to new receptor functionalities. Adenosine receptors (A₁R or A_2AR) can form A₁R-A_2AR heteromers (A₁-A_2AHet), and their activation leads to canonical G-protein-dependent (adenylate cyclase mediated) and -independent (β-arrestin mediated) signaling. Adenosine has different affinities for A₁R and A_2AR, allowing the heteromeric receptor to detect its concentration by integrating the downstream G_i- and G_s-dependent signals. cAMP accumulation and β-arrestin recruitment assays have shown that, within the complex, activation of A_2AR impedes signal

SUBMITTER: Navarro G 

PROVIDER: S-EPMC6389107 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature