Genome-wide association studies and genomic prediction of breeding values for calving performance and body conformation traits in Holstein cattle.

ABSTRACT:

Background

Our aim was to identify genomic regions via genome-wide association studies (GWAS) to improve the predictability of genetic merit in Holsteins for 10 calving and 28 body conformation traits. Animals were genotyped using the Illumina Bovine 50 K BeadChip and imputed to the Illumina BovineHD BeadChip (HD). GWAS were performed on 601,717 real and imputed single nucleotide polymorphism (SNP) genotypes using a single-SNP mixed linear model on 4841 Holstein bulls with breeding value predictions and followed by gene identification and in silico functional analyses. The association results were further validated using five scenarios with different numbers of SNPs.

Results

Seven hundred and eighty-two SNPs were significantly associated with calving performance at a genome-

SUBMITTER: Abo-Ismail MK 

PROVIDER: S-EPMC6389134 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature