ATF-3/miR-590/GOLPH3 signaling pathway regulates proliferation of breast cancer.

ABSTRACT:

Background

Breast cancer is one of the leading causes of death in women worldwide. Fast growth is the important character of breast cancer, which makes sure the subsequent metastasize and invasion breast cancer. Golgi related genes GOLPH3 has been reported to regulate many kinds of cancers proliferation. However, its upregulator remains largely unknown. miRNA modulate gene expression by post-transcriptional repression to participate in many signaling pathway of breast cancer cell proliferation. miR-590 has been reported to regulate tumorgenesis and could be regulated by its own target ATF-3. But whether miR-590 can be the modulator of Golgi related genes to regulate the breast cancer proliferation is unclear.

Methods

We performed the bioinformatics analysis of survival rate

SUBMITTER: Song Q 

PROVIDER: S-EPMC6389151 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature